Biofabrication

Biofabrication is the automated production of tissues and organs to address health challenges in medicine. It uses the principles of additive manufacturing – often termed 3D printing – to combine cells, gels and materials into a single construct that can replace a diseased or injured tissue. The final product is often complex and contains a number of various components including structural and cellular constituents. It is distinguished from tissue engineering in the use of automation in the fabrication of the tissue construct.

3D bioprinting is one technique used within biofabrication. Initially used as a rudimentary extrusion technique, recent advances in granular hydrogels, volumetric bioprinting and modular tissue assembly give diversity to the young 3D bioprinting field.

Recent Classic Papers

• Kuzucu (Extrusion-Based 3D Bioprinting of Gradients of Stiffness, Cell Density, and Immobilized Peptide Using Thermogelling Hydrogels)
• Liu (Bio‐assembling Macro‐Scale, Lumenized Airway Tubes of Defined Shape via Multi‐Organoid Patterning and Fusion)
• Bernal (Volumetric Bioprinting of Complex Living-Tissue Constructs within Seconds)
• Daly (3D bioprinting of high cell-density heterogeneous tissue models)
• Grigoryan (Multivascular networks and functional intravascular topologies within biocompatible hydrogels)
• Highley (Jammed Microgel Inks for 3D Printing Applications)
• Kaynak (Addressable Acoustic Actuation of 3D Printed Soft Robotic Microsystems)
• Liashenko (Ultrafast 3D printing with submicrometer features using electrostatic jet deflection)
• Liashenko (Designing Outside the Box Unlocking the Geometric Freedom of Melt Electrowriting using Microscale Layer Shifting)
• Skylar-Scott (Voxelated soft matter via multimaterial multinozzle 3D printing)
• Skylar-Scott (Laser-assisted direct ink writing of planar and 3D metal architectures)
• Tumbleston (Continuous liquid interface production of 3D objects)
• Zhang (Continuous 3D printing from one single droplet)

Classic Biofabrication Papers

• Melchels et al. (2012) (Review on Additive Manufacturing)
• Billiet et al. (2012) (Review on Additive Manufacturing)
• Zheng et al. (2012) (Engineering microvessels)
• Melchels et al. (2010) (Scaffolds built with mathematically derived sub-units)
• Malda et al. (2013) (Hydrogel Printing Review)
• Dalton et al. (2013) (Review on electrospinning and additive manufacturing overlap)
• Brown et al. (2011) (Melt Electrospinning Writing)
• Skoog et al. (2014) (Review on SLA & 2-photon polymerization)
• Hollister (2009) (Taking TE to the clinic)